High-Resolution NMR Spectroscopy at Large Fields with Nitrogen Vacancy Centers

Ensembles of nitrogen-vacancy (NV) centers are used as sensors to detect NMR signals from micron-sized samples at room temperature. In this scenario, the regime of large magnetic fields is especially interesting as it leads to a large nuclear thermal polarisation -- thus, to a strong sensor response even in low concentration samples -- while chemical shifts and J-couplings become more accessible. Nevertheless, this regime remains largely unexplored owing to the difficulties to couple NV-based sensors with high-frequency nuclear signals. In this work, we circumvent this problem with a method that maps the relevant energy shifts in the amplitude of an induced nuclear spin signal that is subsequently transferred to the sensor. This stage is interspersed with free-precession periods of the sample nuclear spins where the sensor does not participate. Thus, our method leads to high spectral resolutions ultimately limited by the coherence of the nuclear spin signal.Comment: 6 pages, 3 figure

Evolutionary 3D Image Segmentation of Curve Epithelial Tissues of Drosophila melanogaster

Analysing biological images coming from the microscope is challenging; not only is it complex to acquire the images, but also the three-dimensional shapes found on them. Thus, using automatic approaches that could learn and embrace that variance would be highly interesting for the field. Here, we use an evolutionary algorithm to obtain the 3D cell shape of curve epithelial tissues. Our approach is based on the application of a 3D segmentation algorithm called LimeSeg, which is a segmentation software that uses a particle-based active contour method. This program needs the fine-tuning of some hyperparameters that could present a long number of combinations, with the selection of the best parametrisation being highly time-consuming. Our evolutionary algorithm automatically selects the best possible parametrisation with which it can perform an accurate and non-supervised segmentation of 3D curved epithelial tissues. This way, we combine the segmentation potential of LimeSeg and optimise the parameters selection by adding automatisation. This methodology has been applied to three datasets of confocal images from Drosophila melanogaster, where a good convergence has been observed in the evaluation of the solutions. Our experimental results confirm the proper performing of the algorithm, whose segmented images have been compared to those manually obtained for the same tissues

Tailored Ion Beam for Precise Color Center Creation

We present a unitary quantum control scheme that produces a highly monochromatic ion beam from a Paul trap. Our protocol is implementable by supplying the segmented electrodes with voltages of the order of Volts, which mitigates the impact of fluctuating voltages in previous designs and leads to a low-dispersion beam of ions. Moreover, our proposal does not rely on sympathetically cooling the ions, which bypasses the need of loading different species in the trap -- namely, the propelled ion and, e.g., a $^{40}$Ca$^+$ atom able to exert sympathetic cooling -- incrementing the repetition rate of the launching procedure. Our scheme is based on an invariant operator linear in position and momentum, which enables us to control the average extraction energy and the outgoing momentum spread. In addition, we propose a sequential operation to tailor the transversal properties of the beam before the ejection to minimize the impact spot and to increase the lateral resolution of the implantation

Evolución de la relación entre atención primaria y especializada 1992-2001: estudio Delphi

ObjetivoValorar la tendencia en la relación de atención primaria (AP) y especializada (hospital) en 2 momentos diferentes de la reforma sanitaria, al inicio (1992) y tras una fase de consolidación (2001).DiseñoEstudio cualitativo basado en la técnica Delphi modificada.EmplazamientoComunidad Valenciana.ParticipantesSe seleccionó a un total de 196 profesionales de la Comunidad Valenciana (103 coordinadores de AP, 43 directores médicos hospitalarios y de AP, y 50 jefes de servicio de medicina interna/urgencias).ResultadosSe enviaron 196 cuestionarios, con una tasa de respuesta del 38%. Desde AP los problemas se mantienen, con un empeoramiento en la desmotivación del personal sanitario (+1,34), la falta de visión integral del paciente (+1,10) y la masificación asistencial (+1,06), y un mejoría en la presencia de especialistas de ambulatorio no integrados (–1,32). Desde el ámbito hospitalario empeora la falta de visión integral del paciente (+0,51), pero destaca la mejoría generalizada de los problemas, sobre todo la falta de comunicación y diálogo (–1,14). Las soluciones que aumentan su demanda desde AP son una historia clínica única informatizada (+1,50), la elaboración de protocolos comunes (+0,86) y las rotaciones periódicas de los médicos de AP (MAP) por servicios hospitalarios (+0,85), con una disminución de las derivaciones burocráticas a AP (–0,60) y la necesidad de especialistas en AP como consultores (–0,36). Desde el ámbito hospitalario, todas las soluciones disminuyen su valoración y entre ellas destaca facilitar el acceso de MAP para el seguimiento de los pacientes ingresados (–2,44) y la realización de guardias hospitalarias por MAP (–2,30).ConclusionesLos problemas y las soluciones siguen siendo los mismos que en 1992, pero en AP se observa una tendencia a empeorar y en el ámbito hospitalario se detecta una visión más positiva.AimTo evaluate the trends in the inter-professional relationship between primary health care (PHC) and secondary care (hospital) at 2 different moments of the health reform, at its start in 1992 and after a phase of consolidation (2001).DesignObservational study based on modified Delphi technique.SettingValencia Community, Spain.ParticipantsOne hundred and ninety six professionals from Valencia Community were selected (103 PH centre administrators, 43 hospital and PC medical directors, and 50 heads of internal medicine or emergency services).ResultsOne hundred and ninety six questionnaires were sent out, with a response rate of 38%. In PHC problems remained the same, but the following got worse: “lack of motivation” (+1.34), “lack of overall vision of patients” (+1.10), and “overuse of medical services” (+1.06). The existence of non-integrated out-patient specialists got better (–1.32). In hospitals, “lack of overall vision of patients” got worse (+0.51), but in general problems got better, especially in “lack of communication and dialogue” (–1.14). PC increased its demand for “a single computerized clinical record” (+1.50), drawing up of common protocols (+0.86), and periodic rotations of PC doctors through hospitals (+0.85), but bureaucratic referrals to PC (–0.60) and the need for specialists in PC as consultants (-0.36) diminished. In hospitals all solutions showed lower scores, particularly access of PC doctors to monitoring of admitted patients (–2.44) and PC doctors doing hospital cover (–2.30).ConclusionsProblems and solutions from PHC and hospitals remain the same, but there is a trend to the worse in PHC, whereas in hospitals the trend is more positive

Algebraic Geometry Codes from Castle curves

The quality of an algebraic geometry code depends on the curve from which the code has been defined. In this paper we consider codes obtained from Castle curves, namely those whose number of rational points attains Lewittes' bound for some rational point Q and the Weierstrass semigroup at Q is symmetric

El trabajador social como asesor familiar

Se plantea la necesidad social que las familias tienen de recibir asesoramiento sobre sus problemas, en los diferentes momentos por los que pasan en su ciclo vital, y la oportunidad de la figura del trabajador social para desarrollar tareas encaminadas a proporcionar dicho asesoramiento familiar

Amplified Nanoscale Detection of Labelled Molecules via Surface Electrons on Diamond

The detection of individual molecules and their dynamics has been a long-standing challenge in the field of nanotechnology. In this work, we present a method that utilizes a nitrogen vacancy (NV) center and a dangling-bond on the diamond surface to measure the coupling between two electronic targets tagged on a macromolecule. To achieve this, we design a multi-tone dynamical decoupling sequence that leverages the strong interaction between the nitrogen vacancy center and the dangling bond. In addition, this sequence minimizes the impact of decoherence finally resulting in an increased signal-to-noise ratio. This proposal has the potential to open up new avenues for fundamental research and technological innovation in distinct areas such as biophysics and biochemistry.Comment: 9 pages, 6 figure

CASTLE CURVES AND CODES

We introduce two types of curves of interest for coding theory purposes: the so-called Castle and weak Castle curves. We study the main properties of codes arising from these curves.3439940